Modulation of Intrinsic Circuits in Developing Neocortex
نویسندگان
چکیده
منابع مشابه
Modulation of intrinsic circuits by serotonin 5-HT3 receptors in developing ferret visual cortex.
Serotonergic projections are widespread in the developing neocortex, but their functions are obscure. The effects of 5-HT3 receptor agonists on cortical circuit response properties were studied in slices of ferret primary visual cortex using high-speed optical imaging of voltage-sensitive dye signals and whole-cell patch-clamp recording. Activation of the 5-HT3 receptor decreased the amplitude ...
متن کاملCholinergic modulation of epileptiform activity in the developing rat neocortex.
The effects of carbachol on picrotoxin-induced epileptiform activity and membrane properties of neurons in the developing rat neocortex were examined in an in vitro slice preparation. Intracellular recordings were obtained in layer II-III neurons of slices prepared from rats 9-21 days of age. Epileptiform activity in 9- to 14-day-olds consisted of a sharply rising, sustained (10-30 s) membrane ...
متن کاملNeuronal circuits of the neocortex.
We explore the extent to which neocortical circuits generalize, i.e., to what extent can neocortical neurons and the circuits they form be considered as canonical? We find that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought. Similarly, the inhibitory neu...
متن کاملNeuronal domains in developing neocortex.
The mammalian neocortex consists of a mosaic of columnar units whose development is poorly understood. Optical recordings of brain slices labeled with the fluorescent calcium indicator fura-2 revealed that the neonatal rat cortex was partitioned into distinct domains of spontaneously coactive neurons. In tangential slices, these domains were 50 to 120 micrometers in diameter; in coronal slices ...
متن کاملExperience-dependent plasticity of layer 2/3 circuits in developing somatosensory neocortex
Experience-dependent plasticity is the adaptability of brain circuits as a result of changes in neural activity, a phenomenon that has been proposed as the neural basis for important brain function in health and disease. The underlying mechanisms of experience-dependent plasticity can take different forms, depending on the organisms and brain areas under investigation. A better understanding of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Epilepsia
سال: 2000
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1157.2000.tb00309.x